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In the zone: presynaptic function at high res

Nature Neuroscience volume 15, pages 928–929 (2012)Cite this article

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Despite years of research, what regulates neurotransmitter release at synapses is still not fully understood. Physiological and ultrastructural approaches now reveal critical structural parameters of the presynaptic active zone correlating with release probability: the size of the active zone and the number of calcium channels.

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Figure 1: Size of the active zone correlates with the number of calcium channels, which in turn regulates release probability.

References

  1. Pang, Z.P. & Südhof, T.C. Curr. Opin. Cell Biol. 22, 496–505 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Holderith, N. et al. Nat. Neurosci. 15, 988–997 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sheng, J. et al. Nat. Neurosci. 15, 998–1006 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Palade, G.E. & Palay, S.L. Anat. Rec. 118, 335–336 (1954).

    Google Scholar 

  5. Del Castillo, J. & Katz, B. J. Physiol. (Lond.) 124, 560–573 (1954).

    Article  CAS  Google Scholar 

  6. Katz, B. The Release of Neural Transmitter Substances (Liverpool University Press, Liverpool, 1969).

    Google Scholar 

  7. Korn, H., Triller, A., Mallet, A. & Faber, D.S. Science 213, 898–901 (1981).

    Article  CAS  PubMed  Google Scholar 

  8. Schikorski, T. & Stevens, C.F. Nat. Neurosci. 4, 391–395 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Dodge, F.A. Jr. & Rahamimoff, R. J. Physiol. (Lond.) 193, 419–432 (1967).

    Article  CAS  Google Scholar 

  10. Lou, X., Scheuss, V. & Schneggenburger, R. Nature 435, 497–501 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Oertner, T.G., Sabatini, B.L., Nimchinsky, E.A. & Svoboda, K. Nat. Neurosci. 5, 657–664 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. He, L., Wu, X.S., Mohan, R. & Wu, L.G. Nature 444, 102–105 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. Hoppa, M.B., Lana, B., Margas, W., Dolphin, A.C. & Ryan, T.A. Nature advance online publication, doi:10.1038/nature11033 (13 May 2012).

  14. MacGillavry, H.D., Kerr, J.M. & Blanpied, T.A. Mol. Cell. Neurosci. 48, 321–331 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Kurshan, P.T., Oztan, A. & Schwarz, T.L. Nat. Neurosci. 12, 1415–1423 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Katherine M. Myers and Anna Caputo are in the Department of Neurobiology, Interdepartmental Program in Neuroscience, Felix E. Schweizer, Brain Research Institute, Integrative Center for Learning and Memory, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.,

    Felix E Schweizer, Katherine M Myers & Anna Caputo

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  1. Felix E Schweizer
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  2. Katherine M Myers
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  3. Anna Caputo
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Correspondence to Felix E Schweizer.

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The authors declare no competing financial interests.

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Schweizer, F., Myers, K. & Caputo, A. In the zone: presynaptic function at high res. Nat Neurosci 15, 928–929 (2012). https://doi.org/10.1038/nn.3149

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