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Unwrapping HDAC1 and HDAC2 functions in Schwann cell myelination

Nature Neuroscience volume 14, pages 401–403 (2011)Cite this article

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Two studies now show that epigenetic regulation of gene transcription by histone deacetylases (HDACs) 1 and 2 regulates Schwann cell myelination through activation of a cascade of myelin gene expression. Deletion of HDAC1 and HDAC2 in Schwann cells disrupts interactions with axons, blocks myelination and leads to Schwann cell death.

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Figure 1: HDAC1 and HDAC2 as major regulators of Schwann cell development.

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  1. Department of Neurosciences, The author is at the Center for Translational Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.,

    Robert H Miller

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  1. Robert H Miller
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Correspondence to Robert H Miller.

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The author declares no competing financial interests.

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Miller, R. Unwrapping HDAC1 and HDAC2 functions in Schwann cell myelination. Nat Neurosci 14, 401–403 (2011). https://doi.org/10.1038/nn.2788

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