Article abstract
Nature Neuroscience 12, 1165 - 1170 (2009)
Published online: 16 August 2009 | doi:10.1038/nn.2373
Change detection by thalamic reticular neurons
Xiong-Jie Yu1,2, Xin-Xiu Xu1, Shigang He1 & Jufang He1,2
Abstract
The thalamic reticular nucleus (TRN) is thought to function in the attentional searchlight. We analyzed the detection of deviant acoustic stimuli by TRN neurons and the consequences of deviance detection on the TRN target, the medial geniculate body (MGB) of the rat. TRN neurons responded more strongly to pure-tone stimuli presented as deviant stimuli (low appearance probability) than those presented as standard stimuli (high probability) (deviance-detection index = 0.321). MGB neurons also showed deviance detection in this procedure, albeit to a smaller extent (deviance-detection index = 0.154). TRN neuron deviance detection either enhanced (14 neurons) or suppressed (27 neurons) MGB neuronal responses to a probe stimulus. Both effects were neutralized by inactivation of the auditory TRN. Deviance modulation effects were cross-modal. Deviance detection probably causes TRN neurons to transiently deactivate surrounding TRN neurons in response to a fresh stimulus, altering auditory thalamus responses and inducing attention shift.
- CAS-Hong Kong Joint Research Laboratory for Visuo-Auditory Integration, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
- Laboratory of Applied Neuroscience, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Correspondence to: Jufang He1,2 e-mail: rsjufang@polyu.edu.hk
Correspondence to: Shigang He1 e-mail: shiganghe@moon.ibp.ac.cn
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