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Who let the spikes out?

Nature Neuroscience volume 12, pages 959–960 (2009)Cite this article

Quantitative immunostaining, electrophysiology and modeling show that two sodium channel isoforms are asymmetrically distributed in the axon initial segment. Their polarized distribution explains many of the unique properties of the axon initial segment, including its ability to both initiate spikes and guarantee subsequent backpropagation.

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Figure 1: A new blueprint for action potential initiation in the AIS.

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Authors and Affiliations

  1. Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA

    Chris G Dulla & John R Huguenard

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  1. Chris G Dulla
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  2. John R Huguenard
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Dulla, C., Huguenard, J. Who let the spikes out?. Nat Neurosci 12, 959–960 (2009). https://doi.org/10.1038/nn0809-959

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