News and Views
Nature Neuroscience 12, 959 - 960 (2009)
doi:10.1038/nn0809-959
Who let the spikes out?
Chris G Dulla1 & John R Huguenard1
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The authors are at the Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
e-mail: john.huguenard@stanford.edu
Abstract
Quantitative immunostaining, electrophysiology and modeling show that two sodium channel isoforms are asymmetrically distributed in the axon initial segment. Their polarized distribution explains many of the unique properties of the axon initial segment, including its ability to both initiate spikes and guarantee subsequent backpropagation.
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