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Stop and go GABA

A recent study shows that GABA switches from stimulating to inhibiting interneuron motility during neocortical development. This change in response is gated by the expression of the chloride transporter KCC2.

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Figure 1: KCC2 expression acts as a molecular switch for interneuron migration.

References

  1. Cobos, I., Borello, U. & Rubenstein, J.L. Neuron 54, 873–888 (2007).

    Article  CAS  Google Scholar 

  2. Liodis, P. et al. J. Neurosci. 27, 3078–3089 (2007).

    Article  CAS  Google Scholar 

  3. Stumm, R.K. et al. J. Neurosci. 23, 5123–5130 (2003).

    Article  CAS  Google Scholar 

  4. Bortone, D. & Polleux, F. Neuron 62, 53–71 (2009).

    Article  CAS  Google Scholar 

  5. Bolteus, A.J. & Bordey, A. J. Neurosci. 24, 7623–7631 (2004).

    Article  CAS  Google Scholar 

  6. Cuzon, V.C., Yeh, P.W., Cheng, Q. & Yeh, H.H. Cereb. Cortex 16, 1377–1388 (2006).

    Article  Google Scholar 

  7. Farrant, M. & Nusser, Z. Nat. Rev. Neurosci. 6, 215–229 (2005).

    Article  CAS  Google Scholar 

  8. Behar, T.N., Schaffner, A.E., Scott, C.A., Greene, C.L. & Barker, J.L. Cereb. Cortex 10, 899–909 (2000).

    Article  CAS  Google Scholar 

  9. Manent, J.B. et al. J. Neurosci. 25, 4755–4765 (2005).

    Article  CAS  Google Scholar 

  10. Rivera, C. et al. Nature 397, 251–255 (1999).

    Article  CAS  Google Scholar 

  11. Komuro, H. & Rakic, P. Neuron 17, 275–285 (1996).

    Article  CAS  Google Scholar 

  12. Zheng, J.Q. & Poo, M.M. Annu. Rev. Cell Dev. Biol. 23, 375–404 (2007).

    Article  CAS  Google Scholar 

  13. Cancedda, L., Fiumelli, H., Chen, K. & Poo, M.M. J. Neurosci. 27, 5224–5235 (2007).

    Article  CAS  Google Scholar 

  14. Wang, D.D. & Kriegstein, A.R. J. Neurosci. 28, 5547–5558 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Brady J Maher or Joseph J LoTurco.

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Maher, B., LoTurco, J. Stop and go GABA. Nat Neurosci 12, 817–818 (2009). https://doi.org/10.1038/nn0709-817

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