Brief Communication abstract
Nature Neuroscience 12, 826 - 828 (2009)
Published online: 7 June 2009 | doi:10.1038/nn.2349
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li1,5, Wencheng Liu1,5, Tinmarla F Oo2, Lei Wang1,3, Yi Tang1,4, Vernice Jackson-Lewis2, Chun Zhou2, Kindiya Geghman1, Mikhail Bogdanov1,3, Serge Przedborski2, M Flint Beal1, Robert E Burke2 & Chenjian Li1
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.
- Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.
- Departments of Neurology and Pathology, Columbia University, New York, New York, USA.
- Bedford Veterans Administration Medical Center, Bedford, Massachusetts, USA.
- Present address: Department of Neurology, Xuan-Wu Hospital, Beijing, China.
- These authors contributed equally to this work.
Correspondence to: Chenjian Li1 e-mail: chl2011@med.cornell.edu
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