Brief Communication abstract


Nature Neuroscience 12, 826 - 828 (2009)
Published online: 7 June 2009 | doi:10.1038/nn.2349

Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

Yanping Li1,5, Wencheng Liu1,5, Tinmarla F Oo2, Lei Wang1,3, Yi Tang1,4, Vernice Jackson-Lewis2, Chun Zhou2, Kindiya Geghman1, Mikhail Bogdanov1,3, Serge Przedborski2, M Flint Beal1, Robert E Burke2 & Chenjian Li1

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Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

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  1. Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.
  2. Departments of Neurology and Pathology, Columbia University, New York, New York, USA.
  3. Bedford Veterans Administration Medical Center, Bedford, Massachusetts, USA.
  4. Present address: Department of Neurology, Xuan-Wu Hospital, Beijing, China.
  5. These authors contributed equally to this work.

Correspondence to: Chenjian Li1 e-mail: chl2011@med.cornell.edu