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Nature Neuroscience 12, 669 - 671 (2009)
doi:10.1038/nn0609-669
Neurogenesis in G minor
Anne-Marie Marzesco1, Felipe Mora-Bermudez1 & Wieland B Huttner1
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The authors are at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
e-mail: huttner@mpi-cbg.de
Abstract
The orientation of the mitotic spindle determines whether divisions of the polarized neural progenitors in the ventricular zone cause their expansion or lead to neurogenesis. A guanine nucleotide exchange factor for the small GTPase RhoA is now shown to tip this balance in favor of neurogenesis.
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