1. The author is in the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. e-mail: bruce_bean@hms.harvard.edu

Abstract

I_h is an excitatory inward current at subthreshold voltages, but enhancing I_h in CA1 pyramidal neurons leads to inhibition of action potential firing. A report in this issue suggests activation of the potassium current I_M underlies this paradox.

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