1. The authors are at the New York Neural Stem Cell Institute, Rensselaer, New York, USA. e-mail: qinshen@nynsci.org or e-mail: sallytemple@nynsci.org

Abstract

Neural stem cells transition through several progenitor stages before finally generating postmitotic neurons. New work shows that one of these steps, the generation of neuroblasts from transient amplifying precursors in the adult subventricular zone, requires downregulation of the transcription factor Sox9 by the microRNA miR-124.

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