News and Views
Nature Neuroscience 12, 241 - 243 (2009)
Corrected online: 16 March 2009 | doi:10.1038/nn0309-241
How adversity gets under the skin
Steven E Hyman1
- The author is in the Department of Neurobiology, Harvard Medical School, Office of the Provost, Massachusetts Hall, Cambridge, Massachusetts 02138, USA. e-mail: seh@harvard.edu
Abstract
Rat models implicate epigenetic regulation of hippocampal glucocorticoid receptor expression in mediating the effects of early life experience on adult behavior. A report now suggests that the same mechanism might also be at work in humans.
* In the version of this article initially published, the first sentence of the first full paragraph on p. 243 should read: "Turning to the potential epigenetic mechanisms underlying these changes in glucocorticoid receptor expression, McGowan et al.1 found that there are higher levels of exon 1F methylation in suicide victims with a history of being abused than in nonabused suicide victims or controls." The error has been corrected in the HTML and PDF versions of the article.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuseNature Neuroscience Article (01 Mar 2009)
Epigenetic programming by maternal behaviorNature Neuroscience Article (01 Aug 2004)
See all 3 matches for Research
