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Nature Neuroscience 12, 108–110 (1 February 2009) | doi:10.1038/nn0209-108
PML: a tumor suppressor essential for neocortical development
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Abstract
Construction of the neocortex requires a remarkably complex balancing act between the maintenance and proliferation of the neural progenitor cell (NPC) pool, on the one hand, and the differentiation of daughter cells into neurons and glial cells on the other. Although many signaling pathways have been shown to regulate this process (for example, Notch, Wnt, FGF), relatively little is known about the role of cell cycle regulators.
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