News and Views
Nature Neuroscience 12, 108 - 110 (2009)
doi:10.1038/nn0209-108
PML: a tumor suppressor essential for neocortical development
Karisa C Schreck1 & Nicholas Gaiano1
- Karisa C. Schreck is at the Institute for Cell Engineering and the Department of Neuroscience, and Nicholas Gaiano is at the Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. e-mail: kschreck@jhmi.edu or e-mail: gaiano@jhmi.edu.
Abstract
Brain development requires precise control of progenitor proliferation and differentiation. PML appears to be a crucial regulator of cortical progenitors, limiting proliferation and promoting the generation of committed neuronal precursors.
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