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Nature Neuroscience 12, 107 - 108 (2009)
doi:10.1038/nn0209-107
Too much Sonic, too few neurons
Christopher A Fasano1 & Lorenz Studer1
- The authors are at the Sloan-Kettering Institute for Cancer Research, Developmental Biology Program and Department of Neurosurgery, 1275 York Avenue, New York, New York 10065, USA. e-mail: fasanoc@mskcc.org or e-mail: studerl@mskcc.org
Abstract
The floor plate can generate neurons, but does so only in the midbrain. New work shows that Shh suppresses floor plate neurogenesis, and that in the midbrain, Wnt downregulates Shh expression via canonical signaling through 
-catenin.
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