Brief Communication abstract
Nature Neuroscience 12, 119 - 121 (2008)
Published online: 4 January 2009 | doi:10.1038/nn.2240
Collagen VI protects neurons against A
toxicity
Jason S Cheng1,6, Dena B Dubal1,2,6, Daniel H Kim1, Justin Legleiter1,2,5, Irene H Cheng1,2,5, Gui-Qiu Yu1, Ina Tesseur3, Tony Wyss-Coray3, Paolo Bonaldo4 & Lennart Mucke1,2
Amyloid-
(A) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented A neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of A oligomers with neurons, enhanced A aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
- Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, USA.
- Department of Neurology, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA.
- Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
- University of Padova, Viale G. Colombo 3, I-35100 Padova, Italy.
- Present addresses: Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA (J.L.), and National Yang Ming University, Institute of Brain Science, 155 Li-Nong Street, Section 2 Shi-Pai, Taipei, R.O.C. (I.H.C.).
- These authors contributed equally to this work.
Correspondence to: Lennart Mucke1,2 e-mail: lmucke@gladstone.ucsf.edu
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