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Brief Communication

Nature Neuroscience 12, 1491–1493 (1 December 2009) | doi:10.1038/nn.2440

Self-generated theta oscillations in the hippocampus

Romain Goutagny , Jesse Jackson & Sylvain Williams

Hippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In contrast, using a complete rat hippocampus in vitro, we found several intrinsic, atropine-resistant theta generators in CA1.