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Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons

Nature Neuroscience volume 12, pages 1485–1487 (2009)Cite this article

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Abstract

The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na+ spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by localized downregulation of A-type K+ channel function. Thus, dendritic plasticity might be used to store recent experience in individual branches of the dendritic arbor.

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Figure 1: Hierarchical distribution of propagation strength of dendritic spikes in CA1 pyramidal cells of control and enriched rats.
Figure 2: Coupling and dV/dtD in strong and weak dendritic families.
Figure 3: A-type K+ channel function is reduced by enrichment in terminal daughter dendrites of strong dendritic families.

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  • 17 November 2009

    In the version of this article initially published online, the author affiliation of Jeffrey C Magee was incorrect. Jeffrey C Magee is at the Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA. The error has been corrected for the print, PDF and HTML versions of this article.

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Author notes

  1. Attila Losonczy & Quan Wen

    Present address: Present address: Department of Neuroscience, Columbia University, New York, New York, USA (A.L.), Department of Physics, Harvard University, Cambridge, Massachusetts, USA (Q.W.).,

Authors and Affiliations

  1. Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA

    Judit K Makara, Attila Losonczy, Quan Wen & Jeffrey C Magee

Authors
  1. Judit K Makara
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  2. Attila Losonczy
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  3. Quan Wen
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  4. Jeffrey C Magee
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Contributions

J.K.M. and J.C.M. designed the study. J.K.M. and A.L. conducted the electrophysiological recordings. J.K.M. analyzed most of the electrophysiological data. Q.W. performed and analyzed cell reconstructions. J.K.M. and J.C.M. wrote the paper.

Corresponding authors

Correspondence to Judit K Makara or Jeffrey C Magee.

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Supplementary Figures 1–5 and Supplementary Methods (PDF 622 kb)

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Makara, J., Losonczy, A., Wen, Q. et al. Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons. Nat Neurosci 12, 1485–1487 (2009). https://doi.org/10.1038/nn.2428

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