Brief Communication abstract
Nature Neuroscience 12, 1491 - 1493 (2009)
Published online: 1 November 2009 | doi:10.1038/nn.2440
Self-generated theta oscillations in the hippocampus
Romain Goutagny1,2, Jesse Jackson1,2 & Sylvain Williams1
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Top of pageHippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In contrast, using a complete rat hippocampus in vitro, we found several intrinsic, atropine-resistant theta generators in CA1. These oscillators were organized along the septotemporal axis and arose independently from CA3. Our results suggest that CA1 theta rhythm can emerge from the coupling of multiple autonomous hippocampal theta oscillators.
- Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montréal, Québec, Canada.
- These authors contributed equally to this work.
Correspondence to: Sylvain Williams1 e-mail: sylvain.williams@douglas.mcgill.ca
