Brief Communication abstract


Nature Neuroscience 12, 1222 - 1223 (2009)
Published online: 13 September 2009 | Corrected online: 20 September 2009 | doi:10.1038/nn.2384

Selective suppression of hippocampal ripples impairs spatial memory

Gabrielle Girardeau1,3, Karim Benchenane1,3, Sidney I Wiener1, György Buzsáki2 & Michaël B Zugaro1

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Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

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  1. Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.
  2. Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.
  3. These authors contributed equally to this work.

Correspondence to: Michaël B Zugaro1 e-mail: michael.zugaro@college-de-france.fr

Correspondence to: György Buzsáki2 e-mail: buzsaki@axon.rutgers.edu

* In the version of this supplementary file originally posted online, part of Supplementary Figure 3 was missing. The error has been corrected in this file as of 20 September 2009. In addition, Gabrielle Girardeau was incorrectly listed as a corresponding author in the HTML version that was originally posted online. The correct corresponding author is György Buzsáki. The error has been corrected in the HTML version of the article.

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