Brief Communication abstract
Nature Neuroscience 12, 1222 - 1223 (2009)
Published online: 13 September 2009 | Corrected online: 20 September 2009 | doi:10.1038/nn.2384
Selective suppression of hippocampal ripples impairs spatial memory
Gabrielle Girardeau1,3,2, Karim Benchenane1,3, Sidney I Wiener1, György Buzsáki2 & Michaël B Zugaro1
Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
- Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.
- Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.
- These authors contributed equally to this work.
Correspondence to: Michaël B Zugaro1 e-mail: michael.zugaro@college-de-france.fr
Correspondence to: György Buzsáki2 e-mail: buzsaki@axon.rutgers.edu
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