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Nature Neuroscience 11, 987–988 (1 September 2008) | doi:10.1038/nn0908-987

Epigenetic control of myelin repair

Brian Popko

Multiple sclerosis is a chronic autoimmune disease of the CNS in which an immune response develops against the myelin sheath and/or oligodendrocytes, the myelinating cell of the CNS. Multiple sclerosis is the most common neurological disorder of young adults, with an estimated incidence of approximately 1 in 500 individuals, resulting in annual global health care and associated costs in the tens of billions of dollars.