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Brief Communication
Nature Neuroscience 11, 998–1000 (1 September 2008) | doi:10.1038/nn.2167
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
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Abstract
The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter.
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