Article abstract
Nature Neuroscience 11, 1059 - 1067 (2008)
Published online: 1 August 2008 | doi:10.1038/nn.2164
A subset of octopaminergic neurons are important for Drosophila aggression
Chuan Zhou1,2, Yong Rao1 & Yi Rao1,3
Abstract
Aggression is an innate behavior that is important for animal survival and evolution. We examined the molecular and cellular mechanisms underlying aggression in Drosophila. Reduction of the neurotransmitter octopamine, the insect equivalent of norepinephrine, decreased aggression in both males and females. Mutants lacking octopamine did not initiate fighting and did not fight other flies, although they still provoked other flies to fight themselves. Mutant males lost to the wild-type males in fighting and in competing for copulation with females. Enhanced octopaminergic signaling increased aggression in socially grouped flies, but not in socially isolated flies. We carried out genetic rescue experiments that revealed the functional importance of neuronal octopamine and identified a small subset of octopaminergic neurons in the suboesophageal ganglion as being important for aggression.
- National Institute of Biological Sciences, Beijing, 7 Zhongguanchun Life Sciences Park, Beijing 102206, China.
- Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd., Chaoyang District, Beijing 100101, China.
- School of Life Sciences and State Key Laboratory of Biomembrane, Peking University, 5 Yiheyuan Rd., Haidian District, Beijing 100871, China.
Correspondence to: Yi Rao1,3 e-mail: yrao@pku.edu.cn.
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