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Nature Neuroscience 11, 859–861 (1 August 2008) | doi:10.1038/nn0808-859
Fresh air is good for nerves: hypoxia disturbs axon guidance
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Abstract
Oxygen is critical for the function and survival of all eukaryotic cells; consequently, cells have developed various protective mechanisms for coping with hypoxia. Neurons are the cells most sensitive to hypoxic insults and hypoxia causes a number of human neurological diseases, such as perinatal brain injury, ischemic stroke and hypoxic encephalopathy as a result of circulatory collapse.
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