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Nature Neuroscience 11, 859 - 861 (2008)
doi:10.1038/nn0808-859
Fresh air is good for nerves: hypoxia disturbs axon guidance
Chun-Liang Pan1 & Gian Garriga1
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The authors are at the Helen Wills Neuroscience Institute and the Department of Molecular and Cell Biology, 16 Barker Hall, University of California, Berkeley, California 94720-3204, USA.
e-mail: garriga@berkeley.edu
Abstract
The transcription factor hypoxia-inducible factor 1 (HIF-1) triggers multiple cellular responses to cope with hypoxia. A study in this issue suggests that elevated HIF-1 also causes axon guidance defects under hypoxic conditions.
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