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Brief Communication
Nature Neuroscience 11, 744–745 (1 July 2008) | doi:10.1038/nn.2125
Spike timing|[ndash]|dependent long-term depression requires presynaptic NMDA receptors
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Abstract
NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.
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