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Brief Communication
Nature Neuroscience 11, 741–743 (1 July 2008) | doi:10.1038/nn.2127
Critical role of TRPC6 channels in the formation of excitatory synapses
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Abstract
The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB–dependent pathway.
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