Brief Communication abstract
Nature Neuroscience 11, 752 - 753 (2008)
Published online: 15 June 2008 | doi:10.1038/nn.2139
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Michael Lutter1, Ichiro Sakata2, Sherri Osborne-Lawrence2, Sherry A Rovinsky2, Jason G Anderson2, Saendy Jung1, Shari Birnbaum1, Masashi Yanagisawa3, Joel K Elmquist1,2,4, Eric J Nestler1 & Jeffrey M Zigman2
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
- Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
- Department of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism), The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
- Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
- Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
Correspondence to: Jeffrey M Zigman2 e-mail: jeffrey.zigman@utsouthwestern.edu
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