News and Views


Nature Neuroscience 11, 528 - 529 (2008)
doi:10.1038/nn0508-528

Fire in the hole: pore dilation of the capsaicin receptor TRPV1

Diana Bautista1 & David Julius1

  1. The authors are in the Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, USA.
    e-mail: julius@cmp.ucsf.edu


The capsaicin receptor TRPV1 is important in pain sensation. A new study suggests that this nonselective cation channel shows dynamic alterations in ion permeability, which may contribute to mechanisms of pain hypersensitivity.

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