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Nature Neuroscience 11, 528 - 529 (2008)
doi:10.1038/nn0508-528
Fire in the hole: pore dilation of the capsaicin receptor TRPV1
Diana Bautista1 & David Julius1
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The authors are in the Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, USA.
e-mail: julius@cmp.ucsf.edu
Abstract
The capsaicin receptor TRPV1 is important in pain sensation. A new study suggests that this nonselective cation channel shows dynamic alterations in ion permeability, which may contribute to mechanisms of pain hypersensitivity.
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RESEARCH
TRPV1 shows dynamic ionic selectivity during agonist stimulationNature Neuroscience Article (01 May 2008)
