Brief Communication abstract
Nature Neuroscience 11, 538 - 540 (2008)
Published online: 6 April 2008 | doi:10.1038/nn.2104
Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat
Wenbin Tan1,3, Wiktor A Janczewski1,3, Paul Yang1, Xuesi M Shao1, Edward M Callaway2 & Jack L Feldman1
Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBötzinger Complex (preBötC). Rapid silencing of these neurons in awake rats induced a persistent apnea without any respiratory movements to rescue their breathing. We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure.
- Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, California 90095, USA.
- System Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
- These authors contributed equally to this work.
Correspondence to: Jack L Feldman1 e-mail: feldman@ucla.edu
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