Article abstract
Nature Neuroscience 11, 429 - 439 (2008)
Published online: 16 March 2008 | doi:10.1038/nn2074
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain
Anju Vasudevan1, Jason E Long2, James E Crandall3, John L R Rubenstein2 & Pradeep G Bhide1
Abstract
Prevailing notions of cerebral vascularization imply that blood vessels sprout passively into the brain parenchyma from pial vascular plexuses to meet metabolic needs of growing neuronal populations. Endothelial cells, building blocks of blood vessels, are thought to be homogeneous in the brain with respect to their origins, gene expression patterns and developmental mechanisms. These current notions that cerebral angiogenesis is regulated by local environmental signals contrast with current models of cell-autonomous regulation of neuronal development. Here we demonstrate that telencephalic angiogenesis in mice progresses in an orderly, ventral-to-dorsal gradient regulated by compartment-specific homeobox transcription factors. Our data offer new perspectives on intrinsic regulation of angiogenesis in the embryonic telencephalon, call for a revision of the current models of telencephalic angiogenesis and support novel roles for endothelial cells in brain development.
- Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
- Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158, USA.
- E.K. Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA.
Correspondence to: Pradeep G Bhide1 e-mail: bhide@helix.mgh.harvard.edu
Correspondence to: Anju Vasudevan1 e-mail: anju.vasudevan@mgh.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Telencephalic oligodendrocytes battle it outNature Neuroscience News and Views (01 Feb 2006)
Amygdala and neocortex: common origins and shared mechanismsNature Neuroscience News and Views (01 Sep 2007)
See all 3 matches for News And ViewsRESEARCH
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migrationThe EMBO Journal Article (21 Dec 2005)
β-catenin?mediated Wnt signaling regulates neurogenesis in the ventral telencephalonNature Neuroscience Article (01 Dec 2008)
See all 56 matches for Research
