News and Views
Nature Neuroscience 11, 381 - 382 (2008)
doi:10.1038/nn0408-381
NMDA receptor activity regulates transcription of antioxidant pathways
Stuart A Lipton1
- The author is at The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, with adjunct appointments at The Salk Institute for Biological Studies, The Scripps Research Institute and the University of California at San Diego, all in La Jolla, California 92037, USA. e-mail: slipton@burnham.org or e-mail: slipton@ucsd.edu
Abstract
How neurons might protect themselves from free radical damage has been a mystery. A new study suggests that synaptic NMDA receptor activity affords neuroprotection by regulating oxidation-reduction (redox) pathways via transcription.
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