News and Views


Nature Neuroscience 11, 244 - 246 (2008)
doi:10.1038/nn0308-244

bold beta-catenin in reverse action

Amy K Y Fu1, Zelda H Cheung1 & Nancy Y Ip1

  1. The authors are at the Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. e-mail: boip@ust.hk


Motor neurons and muscle fibers interact in complex ways to build the neuromuscular synapse. A new study shows that beta-catenin is required in muscle to provide an unknown retrograde signal that is necessary for presynaptic transmitter release.

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