Article abstract
Nature Neuroscience 11, 209 - 215 (2008)
Published online: 13 January 2008 | doi:10.1038/nn2037
Reactivation of experience-dependent cell assembly patterns in the hippocampus
Joseph O'Neill1, Timothy J Senior1, Kevin Allen1, John R Huxter1 & Jozsef Csicsvari1
Abstract
The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies (<50 ms) during exploration, and was strongest between cells representing the most visited places. This is indicative of a Hebbian learning rule in which changes in firing associations between cells are determined by the number of waking coincident firing events. In contrast, cells encoding different locations reduced their cofiring in proportion to the number of times that they fired independently. Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior.
- Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Correspondence to: Jozsef Csicsvari1 e-mail: jozsef.csicsvari@pharm.ox.ac.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Crossing borders: sleep reactivation as a window on cell assembly formationNature Neuroscience News and Views (01 Feb 2008)
Neurobiology Interneurons take chargeNature News and Views (20 Feb 2003)
See all 3 matches for News And ViewsRESEARCH
Induction of sharp wave?ripple complexes in vitro and reorganization of hippocampal networksNature Neuroscience Article (01 Nov 2005)
See all 25 matches for Research