Article abstract
Nature Neuroscience 11, 1383 - 1391 (2008)
Published online: 9 November 2008 | doi:10.1038/nn.2226
-catenin–mediated Wnt signaling regulates neurogenesis in the ventral telencephalon
Alexandra A Gulacsi1,2 & Stewart A Anderson1
Abstract
Development of the telencephalon involves the coordinated growth of diversely patterned brain structures. Previous studies have demonstrated the importance of 
-catenin–mediated Wnt signaling in proliferation and fate determination during cerebral cortical development. We found that -catenin–mediated Wnt signaling critically maintained progenitor proliferation in the subcortical (pallidal) telencephalon. Targeted deletion of -catenin in mice severely impaired proliferation in the medial ganglionic eminence without grossly altering differentiated fate. Several lines of evidence suggest that this phenotype is primarily the result of a loss of canonical Wnt signaling. As previous studies have suggested that the ventral patterning factor Sonic Hedgehog (Shh) also stimulates dorsal telencephalic proliferation, we propose a model whereby Wnt and Shh signaling promote distinct dorsal-ventral patterning while also having broader effects on proliferation that serve to coordinate the growth of telencephalic subregions.
- Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, New York, 10065, USA.
- Present address: Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.
Correspondence to: Stewart A Anderson1 e-mail: saa2007@med.cornell.edu
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