Brief Communication abstract
Nature Neuroscience 11, 1149 - 1151 (2008)
Published online: 7 September 2008 | doi:10.1038/nn.2190
ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval
Alina Elkobi1, Ingrid Ehrlich2, Katya Belelovsky1, Liza Barki-Harrington1 & Kobi Rosenblum1
The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones.
- Center for Brain and Behavior, Department of Neurobiology and Ethology, University of Haifa, Haifa 30905, Israel.
- Friedrich Miescher Institute, Maulbeerstrasse 66, 4057 Basel, Switzerland.
Correspondence to: Kobi Rosenblum1 e-mail: kobir@psy.haifa.ac.il
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