Brief Communication abstract
Nature Neuroscience 11, 1140 - 1142 (2008)
Published online: 7 September 2008 | doi:10.1038/nn.2188
Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex
Nicholas Wright1, Stanislaw Glazewski1,2, Neil Hardingham1, Keith Phillips1, Eleftheria Pervolaraki1 & Kevin Fox1
Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III–V, pathway.
- Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK.
- School of Life Sciences, Keele University, Staffordshire, Keele ST5 5BG, UK.
Correspondence to: Kevin Fox1 e-mail: foxkd@cardiff.ac.uk
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