Article abstract


Nature Neuroscience 11, 1162 - 1167 (2008)
Published online: 31 August 2008 | doi:10.1038/nn.2181

Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex

Tara Keck1, Thomas D Mrsic-Flogel1,3, Miguel Vaz Afonso1, Ulf T Eysel2, Tobias Bonhoeffer1 & Mark Hübener1


The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical connections, but the dynamics of this reorganization process remain unknown. We used repeated intrinsic signal and two-photon imaging to monitor functional and structural alterations in adult mouse visual cortex over a period of months following a retinal lesion. The rate at which dendritic spines were lost and gained increased threefold after a small retinal lesion, leading to an almost complete replacement of spines in the deafferented cortex within 2 months. Because this massive remodeling of synaptic structures did not occur when all visual input was removed, it likely reflects the activity-dependent establishment of new cortical circuits that serve the recovery of visual responses.

Top
  1. Max Planck Institute of Neurobiology, Am Klopfersptiz 18, D-82152 Martinsried, Germany.
  2. Department of Neurophysiology, Ruhr University Bochum, Universitätsstrasse 150, D-44780 Bochum, Germany.
  3. Present address: Department of Physiology, University College London, 21 University Street, London, WC1E 6JJ, UK.

Correspondence to: Mark Hübener1 e-mail: mark@neuro.mpg.de



MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Eyes wide shut

Nature Neuroscience News and Views (01 Dec 1999)

Changing tune in auditory cortex

Nature Neuroscience News and Views (01 Mar 2010)