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Nature Neuroscience 11, 6–8 (1 January 2008) | doi:10.1038/nn0108-6
Dynamin-independent synaptic vesicle retrieval?
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Abstract
A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission. Among the most astonishing mutants in flies are the temperature-sensitive alleles of shibire. These mutants are paralyzed when their temperature is raised to 30 |[deg]|C, yet they resume activity rapidly after their return to 25 |[deg]|C.
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