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Brief Communication

Nature Neuroscience 10, 1131–1133 (1 September 2007) | doi:10.1038/nn1949

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Michael Lazarus , Kyoko Yoshida , Roberto Coppari , Caroline E Bass , Takatoshi Mochizuki , Bradford B Lowell & Clifford B Saper

Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response.