Brief Communication abstract
Nature Neuroscience 10, 1134 - 1136 (2007)
Published online: 12 August 2007 | doi:10.1038/nn1965
Experience-dependent recovery of vision following chronic deprivation amblyopia
Hai-Yan He1, Baisali Ray2, Katie Dennis1 & Elizabeth M Quinlan1,2
The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In addition, the loss of visual acuity resulting from chronic monocular deprivation is reversed if dark exposure precedes removal of the occlusion in adulthood, suggesting a potential use for dark exposure in the treatment of adult amblyopia.
- Department of Biology, 1210 Biology/Psychology Building no. 144, University of Maryland, College Park, Maryland 20742, USA.
- Department of Neuroscience and Cognitive Sciences Program, 1210 Biology/Psychology Building no. 144, University of Maryland, College Park, Maryland 20742, USA.
Correspondence to: Elizabeth M Quinlan1,2 e-mail: equinlan@umd.edu
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