Brief Communication abstract
Nature Neuroscience 10, 1128 - 1130 (2007)
Published online: 5 August 2007 | doi:10.1038/nn1952
Cell type–specific gating of perisomatic inhibition by cholecystokinin
Csaba Földy1, Soo Yeun Lee1, János Szabadics1, Axel Neu1 & Ivan Soltesz1
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
- Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280, USA.
Correspondence to: Csaba Földy1 e-mail: cfoldy@uci.edu
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