Brief Communication abstract
Nature Neuroscience 10, 1131 - 1133 (2007)
Published online: 5 August 2007 | doi:10.1038/nn1949
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
Michael Lazarus1,5, Kyoko Yoshida1, Roberto Coppari2,3, Caroline E Bass4, Takatoshi Mochizuki1, Bradford B Lowell2 & Clifford B Saper1
Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
- Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
- Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
- Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
- Department of Physiology and Pharmacology, Wake Forest University Health Sciences, 115 S. Chestnut St, Winston-Salem, North Carolina 27157, USA.
- Present address: Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4, Furuedai, Suita, Osaka 565-0874, Japan.
Correspondence to: Clifford B Saper1 e-mail: csaper@bidmc.harvard.edu
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