News and Views
Nature Neuroscience 10, 1083 - 1084 (2007)
doi:10.1038/nn0907-1083
RNA decay back in play
Carol L Peebles1 & Steven Finkbeiner1
- The authors are at the Gladstone Institute of Neurological Disease, 1650 Owens St., San Francisco, California 94158, USA, and are affiliated with the Neuroscience Graduate Program, Medical Scientist Training Program, University of California, San Francisco, California 94158. Steven Finkbeiner is also affiliated with the Departments of Neurology and Physiology, University of California, San Francisco, California 94143. e-mail: sfinkbeiner@gladstone.ucsf.edu
Abstract
Lasting synaptic plasticity requires precise local regulation of protein expression. A recent paper reports that the postsynaptic activity–induced arc mRNA is a target for rapid degradation by the 'nonsense-mediated decay' pathway.
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