About the cover

August 2007 Volume 10 No 8

Dellisanti and colleagues solved the crystal structure of the N-terminal extracellular domain of the mouse nicotinic acetylcholine receptor (nAChR) alpha1 subunit, then used structure-guided mutagenesis and patch-clamp recording to identify a hydrophilic patch inside the beta sandwich that is important for agonist-induced channel opening. The cover shows a ribbon model of mouse nAChR alpha1 subunit extracellular domain (dark blue) mounted into a surface model of intact nAChR based on electron microscopy of Torpedo nAChR. Magenta, carbohydrate chain; red, buried water; light blue, alpha-bungarotoxin. (pp 937 and 953)