Brief Communication abstract
Nature Neuroscience 10, 949 - 951 (2007)
Published online: 1 July 2007 | doi:10.1038/nn1931
Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala
Thomas A Stalnaker1, Matthew R Roesch1, Theresa M Franz1, Donna J Calu2, Teghpal Singh2 & Geoffrey Schoenbaum1,3,4
Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.
- Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St., HSF-2 S251, Baltimore, Maryland 21201, USA.
- Program in Neuroscience, University of Maryland School of Medicine, 20 Penn St., HSF-2 S251, Baltimore, Maryland 21201, USA.
- Department of Psychiatry, University of Maryland School of Medicine, 20 Penn St., HSF-2 S251, Baltimore, Maryland 21201, USA.
- Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
Correspondence to: Thomas A Stalnaker1 e-mail: tstal002@umaryland.edu
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