1. Geoffrey Schoenbaum and Thomas Stalnaker are in the Departments of Anatomy and Neurobiology and Psychiatry, University of Maryland, School of Medicine, 20 Penn Street, HSF-2 S251, Baltimore, Maryland 21201, USA. Geoffrey Schoenbaum is also in the Department of Psychology, University of Maryland Baltimore County, Baltimore, Maryland 21228, USA. e-mail: schoenbg@schoenbaumlab.org
2. Yavin Shaham is in the Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, US National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA.

Abstract

Brain-derived neurotrophic factor (BDNF) is important in regulating synaptic plasticity in the brain areas that process reward information. A new study reports that BDNF in the nucleus accumbens, a brain area critical for the rewarding effects of cocaine, promotes persistent cocaine-seeking behaviors and heightens relapse vulnerability.

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