Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.
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Kim, S., Walsh, C. Numb, neurogenesis and epithelial polarity. Nat Neurosci 10, 812–813 (2007). https://doi.org/10.1038/nn0707-812
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DOI: https://doi.org/10.1038/nn0707-812