Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Numb, neurogenesis and epithelial polarity

Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Numb localization is evolutionarily conserved in fly neuroblast and mammalian neuroepithelium.

Kim Caesar

References

  1. Noctor, S.C., Flint, A.C., Weissman, T.A., Dammerman, R.S. & Kriegstein, A.R. Nature 409, 714–720 (2001).

    Article  CAS  Google Scholar 

  2. Rasin, M.-R. et al. Nat. Neurosci. 10, 819–827 (2007).

    Article  CAS  Google Scholar 

  3. Li, H.S. et al. Neuron 40, 1105–1118 (2003).

    Article  CAS  Google Scholar 

  4. Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N. & Zhong, W. Nature 419, 929–934 (2002).

    Article  CAS  Google Scholar 

  5. Petersen, P.H., Zou, K., Krauss, S. & Zhong, W. Nat. Neurosci. 7, 803–811 (2004).

    Article  CAS  Google Scholar 

  6. Wodarz, A. Curr. Opin. Cell Biol. 17, 475–481 (2005).

    Article  CAS  Google Scholar 

  7. Kuo, C.T. et al. Cell 127, 1253–1264 (2006).

    Article  CAS  Google Scholar 

  8. Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. & Jan, Y.N. Neuron 17, 43–53 (1996).

    Article  CAS  Google Scholar 

  9. Smith, C.A. et al. EMBO J. 26, 468–480 (2007).

    Article  CAS  Google Scholar 

  10. Wakamatsu, Y., Maynard, T.M., Jones, S.U. & Weston, J.A. Neuron 23, 71–81 (1999).

    Article  CAS  Google Scholar 

  11. Zhou, Y. et al. Cell 129, 163–178 (2007).

    Article  CAS  Google Scholar 

  12. Berdnik, D., Torok, T., Gonzalez-Gaitan, M. & Knoblich, J.A. Dev. Cell 3, 221–231 (2002).

    Article  CAS  Google Scholar 

  13. Lien, W.H., Klezovitch, O., Fernandez, T.E., Delrow, J. & Vasioukhin, V. Science 311, 1609–1612 (2006).

    Article  CAS  Google Scholar 

  14. Chenn, A. & Walsh, C.A. Science 297, 365–369 (2002).

    Article  CAS  Google Scholar 

  15. Cappello, S. et al. Nat. Neurosci. 9, 1099–1107 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, S., Walsh, C. Numb, neurogenesis and epithelial polarity. Nat Neurosci 10, 812–813 (2007). https://doi.org/10.1038/nn0707-812

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0707-812

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing