News and Views
Nature Neuroscience 10, 812 - 813 (2007)
doi:10.1038/nn0707-812
Numb, neurogenesis and epithelial polarity
- Seonhee Kim and Chris A. Walsh are at the Division of Genetics, Children's Hospital Boston, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and the Program in Neuroscience, Harvard Medical School, New Research Building, Room 266, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. e-mail: cwalsh@bidmc.harvard.edu
Abstract
Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.
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