Brief Communication abstract
Nature Neuroscience 10, 679 - 681 (2007)
Published online: 29 April 2007 | doi:10.1038/nn1899
Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Alessandro Sale1,3, José Fernando Maya Vetencourt1,3, Paolo Medini2, Maria Cristina Cenni2, Laura Baroncelli1, Roberto De Pasquale1 & Lamberto Maffei1,2
Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.
- Scuola Normale Superiore, Piazza dei Cavalieri, I-56100 Pisa, Italy.
- Institute of Neuroscience, CNR, Via Moruzzi 1, I-56100 Pisa, Italy.
- These authors contributed equally to this work.
Correspondence to: Alessandro Sale1,3 e-mail: a.sale@sns.it
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes?CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy?in SCID-hu Mouse?Derived T CellsMolecular Therapy Original Article
Activation of calcium/calmodulin-dependent protein kinases after traumatic brain injuryJournal of Cerebral Blood Flow & Metabolism Original Article
Environmental enrichment prevents effects of dark-rearing in the rat visual cortexNature Neuroscience Brief Communication (01 Mar 2004)
Experience-dependent recovery of vision following chronic deprivation amblyopiaNature Neuroscience Brief Communication (01 Sep 2007)